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Deletion of JDP2 improves neurological outcomes of traumatic brain injury (TBI) in mice: Inactivation of Caspase-3.
Wang XH, Liu Q, Shao ZT. Wang XH, et al. Biochem Biophys Res Commun. 2018 Oct 12;504(4):805-811. doi: 10.1016/j.bbrc.2018.08.055. Epub 2018 Sep 11. Biochem Biophys Res Commun. 2018. PMID: 30217453
In the study, we attempted to explore the effects of JDP2 on TBI progression both in vivo and in vitro. The wild type (WT) and JDP2 knockout (KO) mice were employed in our study and were subjected to TBI. ...Lipopolysaccharide (LPS) also stimulated JDP2 expre …
In the study, we attempted to explore the effects of JDP2 on TBI progression both in vivo and in vitro. The wild type (WT) and JDP …
Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo.
Ku CC, Wuputra K, Kato K, Pan JB, Li CP, Tsai MH, Noguchi M, Nakamura Y, Liu CJ, Chan TF, Hou MF, Wakana S, Wu YC, Lin CS, Wu DC, Yokoyama KK. Ku CC, et al. Stem Cell Res Ther. 2021 Jun 29;12(1):369. doi: 10.1186/s13287-021-02424-4. Stem Cell Res Ther. 2021. PMID: 34187574 Free PMC article.
Jdp2-KO mice exhibited impaired development of the cerebellum compared with wild-type (WT) mice. ...Moreover, development of the cerebellar lobes in Jdp2-KO mice was altered compared with WT mice. Expression of Slc7a11, Nrf2, and p21(Cip1) was higher in the cerebell …
Jdp2-KO mice exhibited impaired development of the cerebellum compared with wild-type (WT) mice. ...Moreover, development of the cere …
Nuclear microRNA-mediated transcriptional control determines adult microglial homeostasis and brain function.
Li Z, Mao K, Liu L, Xu S, Zeng M, Fu Y, Huang J, Li T, Gao G, Teng ZQ, Sun Q, Chen D, Cheng Y. Li Z, et al. Cell Rep. 2024 Mar 26;43(3):113964. doi: 10.1016/j.celrep.2024.113964. Epub 2024 Mar 13. Cell Rep. 2024. PMID: 38489263 Free article.
Microglia are versatile regulators in brain development and disorders. Emerging evidence links microRNA (miRNA)-mediated regulation to microglial function; however, the exact underlying mechanism remains largely unknown. ...Importantly, we find that increased Pu.1 binding …
Microglia are versatile regulators in brain development and disorders. Emerging evidence links microRNA (miRNA)-mediated regulation t …
Overnight Corticosterone and Gene Expression in Mouse Hippocampus: Time Course during Resting Period.
Jaszczyk A, Stankiewicz AM, Goscik J, Majewska A, Jezierski T, Juszczak GR. Jaszczyk A, et al. Int J Mol Sci. 2023 Feb 1;24(3):2828. doi: 10.3390/ijms24032828. Int J Mol Sci. 2023. PMID: 36769150 Free PMC article.
The examples of such genes are Acer2, Agt, Apod, Aqp4, Etnppl, Fabp7, Fam107a, Fjx1, Fmo2, Galnt15, Gjc2, Heph, Hes5, Htra1, Jdp2, Kif5a, Lfng, Lrg1, Mgp, Mt1, Pglyrp1, Pla2g3, Plin4, Pllp, Ptgds, Ptn, Slc2a1, Slco1c1, Sult1a1, Thbd and Txnip. ...
The examples of such genes are Acer2, Agt, Apod, Aqp4, Etnppl, Fabp7, Fam107a, Fjx1, Fmo2, Galnt15, Gjc2, Heph, Hes5, Htra1, Jdp2, Ki …
Epigenome-wide association study of alcohol consumption in N = 8161 individuals and relevance to alcohol use disorder pathophysiology: identification of the cystine/glutamate transporter SLC7A11 as a top target.
Lohoff FW, Clarke TK, Kaminsky ZA, Walker RM, Bermingham ML, Jung J, Morris SW, Rosoff D, Campbell A, Barbu M, Charlet K, Adams M, Lee J, Howard DM, O'Connell EM, Whalley H, Porteous DJ, McIntosh AM, Evans KL. Lohoff FW, et al. Mol Psychiatry. 2022 Mar;27(3):1754-1764. doi: 10.1038/s41380-021-01378-6. Epub 2021 Dec 2. Mol Psychiatry. 2022. PMID: 34857913 Free PMC article.
Genes annotated to associated CpG sites are implicated in liver and brain function, the cellular response to alcohol and alcohol-associated diseases, including hypertension and Alzheimer's disease. ...Our data are intriguing given the prominent role of glutamate signaling …
Genes annotated to associated CpG sites are implicated in liver and brain function, the cellular response to alcohol and alcohol-asso …
Nuclear translocation of doublecortin-like protein kinase and phosphorylation of a transcription factor JDP2.
Nagamine T, Nomada S, Onouchi T, Kameshita I, Sueyoshi N. Nagamine T, et al. Biochem Biophys Res Commun. 2014 Mar 28;446(1):73-8. doi: 10.1016/j.bbrc.2014.02.075. Epub 2014 Feb 25. Biochem Biophys Res Commun. 2014. PMID: 24582561
By two-hybrid screening using the C-terminal domain of DCLK, Jun dimerization protein 2 (JDP2), a nuclear transcription factor, was identified as zDCLK(kinase)-binding protein. Furthermore, JDP2 served as an efficient substrate for zDCLK(kinase) only when histone wa …
By two-hybrid screening using the C-terminal domain of DCLK, Jun dimerization protein 2 (JDP2), a nuclear transcription factor, was i …
Control of Oxidative Stress and Generation of Induced Pluripotent Stem Cell-like Cells by Jun Dimerization Protein 2.
Chiou SS, Wang SS, Wu DC, Lin YC, Kao LP, Kuo KK, Wu CC, Chai CY, Lin CL, Lee CY, Liao YM, Wuputra K, Yang YH, Wang SW, Ku CC, Nakamura Y, Saito S, Hasegawa H, Yamaguchi N, Miyoshi H, Lin CS, Eckner R, Yokoyama KK. Chiou SS, et al. Cancers (Basel). 2013 Jul 26;5(3):959-84. doi: 10.3390/cancers5030959. Cancers (Basel). 2013. PMID: 24202329 Free PMC article.
JDP2 associates with Nrf2 and MafK (Nrf2-MafK) to increase the transcription of antioxidant response element-dependent genes. Oxidative-stress-inducing reagent led to an increase in the intracellular accumulation of ROS and cell proliferation in Jdp2 knock-out mouse …
JDP2 associates with Nrf2 and MafK (Nrf2-MafK) to increase the transcription of antioxidant response element-dependent genes. Oxidati …
Genome-wide identification, evolution of ATF/CREB family and their expression in Nile tilapia.
Wang XS, Zhang S, Xu Z, Zheng SQ, Long J, Wang DS. Wang XS, et al. Comp Biochem Physiol B Biochem Mol Biol. 2019 Nov;237:110324. doi: 10.1016/j.cbpb.2019.110324. Epub 2019 Aug 26. Comp Biochem Physiol B Biochem Mol Biol. 2019. PMID: 31465879
Duplicates of atf6 were derived from 2R, and duplicates of creb1, crem, jdp2, creb5, atf4, atf5 and atf7 were products of 3R. We also isolated 21 ATF/CREBs, belonging to 6 subfamilies from Nile tilapia. Based on transcriptome data, most members were found to be dominantly …
Duplicates of atf6 were derived from 2R, and duplicates of creb1, crem, jdp2, creb5, atf4, atf5 and atf7 were products of 3R. We also …
Identification of mineralocorticoid receptor target genes in the mouse hippocampus.
van Weert LTCM, Buurstede JC, Sips HCM, Vettorazzi S, Mol IM, Hartmann J, Prekovic S, Zwart W, Schmidt MV, Roozendaal B, Tuckermann JP, Sarabdjitsingh RA, Meijer OC. van Weert LTCM, et al. J Neuroendocrinol. 2019 Aug;31(8):e12735. doi: 10.1111/jne.12735. Epub 2019 Jun 14. J Neuroendocrinol. 2019. PMID: 31121060 Free PMC article.
Brain mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) respond to the same glucocorticoid hormones but can have differential effects on cellular function. ...The present study aimed to identify MR-specific target genes in the hippocampus, a brain …
Brain mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) respond to the same glucocorticoid hormones but can have d …
Mineralocorticoid receptor status in the human brain after dexamethasone treatment: a single case study.
Koning ACAM, Habets PC, Bogaards M, Kroon J, van Santen HM, de Bont JM, Meijer OC. Koning ACAM, et al. Endocr Connect. 2022 Mar 14;11(3):e210425. doi: 10.1530/EC-21-0425. Endocr Connect. 2022. PMID: 35148274 Free PMC article.
OBJECTIVE: In this single case study, we evaluate whether dexamethasone leads to reduced MR activation in the human brain. Brain tissue of an 8-year-old brain tumor patient was used, who suffered chronically from dexamethasone-induced neuropsychiatric symptom …
OBJECTIVE: In this single case study, we evaluate whether dexamethasone leads to reduced MR activation in the human brain. Brain …
14 results